ࡱ> %` bjbj"x"x -\@@SA'''8<'4p'U>P(P(P(P(P((") )-5/5/5/5/^5<9<=$C?hAr=*((**=P(P(>---*P(P(-5-*-5--:1,1P(D( `P]u'*1 2%>0U>1 Bh+NB1B1)"9)-Q)e))))==,X)))U>****d    STANDARD OPERATING PROCEDURE: #UCC010 Title: Disposal of GMM waste from a Class 1/Class 2 UCC Laboratory Effective Date: Approvals (Signature and Date): _____________________________ __________________________ __________________________ Author (Signature) Technical Authority (Signature) Date: 1.0 PURPOSE 1.1 Inactivation and safe disposal of Genetically Modified Micro-organism (GMM) contaminated material and waste from a class 1 and class 2 laboratory. 2.0 SCOPE 2.1 The SOP applies to all labs in UCC where GMM work takes place. A GMM is defined as genetically modified microorganism means any microbiological entity, cellular or non-cellular, capable of replication or of transferring genetic material in which the genetic material has been altered in a way that does not occur naturally by mating and/or by natural recombination. 3.0 RESPONSIBILITY 3.1 It is the responsibility of those working with GMMs to be aware of the necessity of inactivation and safe disposal of GMM contaminated materials and waste. An autoclave inactivation log (autoclave run dates and program details [e.g. 124C for 35 minutes] should be maintained by Lab Manager. 4.0 MATERIALS AND EQUIPMENT Autoclaves are used for the sterilization of GMM waste. Autoclave tape is first placed on the biohazard/autoclave bags containing the GMM waste. The autoclave tape ensures temperature and length of autoclave cycle were adequate to sterilize contents of bag (black stripes across tape appear during a successful sterilization cycle). Spore strips should be used for each autoclave run for class 2 GMM waste (spore strips are not necessary if the autoclave gives a print-out of autoclave run details). 6.0 HEALTH AND SAFETY CONSIDERATIONS The safe disposal of GM contaminated material and waste is critical to researcher and environment alike. PPE such as labcoats and safety glasses are provided to protect employees from possible harm. They should be worn at all times when in the lab. Double gloving is strongly advised when working with GMOs. 7.0 DOCUMENTATION REQUIREMENTS 7.1 An autoclave inactivation log (autoclave run details such as date of run and program details [e.g. 124C for 35 minutes] should be maintained. 8.0 PROCEDURE 8.1 All liquid bacterial GMO cultures must be sterilised before disposal. Generally this can be achieved by autoclaving. All waste disposal autoclaving of waste material MUST be carried out in a designated waste autoclave. Autoclaved liquid waste may be discharged to drains. 8.2 With regard to solid waste, plastic tubes, Universals and Petri dishes for autoclaving must be placed in double thickness, OPEN autoclave bags and the bags contained in strong autoclavable plastic or steel containers to retain any liquids (especially molten agar) during autoclaving. Should an autoclaves not be in working order or for other reasons, the waste needs to be transferred to another autoclave in UCC for sterilization, it is imperative that the waste be transported in a closed container e.g. wheelie bin. Bags should only be half filled (to fit in autoclaves). 8.3 If an autoclave is not available, all solutions and components (loops and pipettes) that have come in contact with bacteria can be placed in a fresh 10% bleach solution for at least 20 minutes for sterilization. 8.4 Persons must wash their hands (with liquid handsoap): (i) after they handle materials involving organisms containing recombinant DNA molecules, and (ii) before exiting the laboratory. 8.5 Animal carcasses are placed in special boxes provided by Brian Rogers at Healthcare Waste (Tel 059-9134811 or 086-8148358). Animals are humanely terminated (cervical dislocation) and carcasses stored at -20 degrees C. They are subsequently collected by waste disposal contractor as mentioned above. All waste is collected by Healthcare Waste Management Ltd. who act as agents for Ecosafe Ltd who are licensed to dispose of GM waste in Ireland. 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