Growth Factor Receptor at Golgi
A research article from the School was published in the prestigious journal Science Signaling and is also featured in a focus article and on the journal cover.
is the first author of this work from the O鈥機onnor group. They discovered that a growth factor receptor, which is normally present on the surface of cells, can under certain conditions relocate to the Golgi apparatus inside cells. Here it helps cancer cells to grow or migrate and avoid drugs that can block the receptor at the cell surface.
The other authors are , , , and Rosemary O鈥機onnor.
The research was funded by through PI investigator awards.
Leonie Rieger, Sandra O鈥橲hea, Grant Godsmark, Joanna Stanicka, Geraldine Kelly, Rosemary O鈥機onnor (2020) IGF-1 receptor activity in the Golgi of migratory cancer cells depends on adhesion-dependent phosphorylation of Tyr1250 and Tyr12 13, Science Signaling eaba3176 (2020) 26 May 2020.
Reprint:
FOCUS
The tale of a tail: The secret behind IGF-1R鈥檚 oncogenic power.
By Caitrin Crudden, Leonard Girnita. Science Signaling 26 May 2020.
The C-terminal tail of IGF-1R promotes cancer cell migration by mediating adhesion-dependent translocation to the Golgi (Rieger et al., in 26 May 2020 issue).