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Methodology Monday November Roundup
To begin November's #MethodologyMonday roundup, Booth et al presents case studies from three NIHR-funded trials demonstrating how publicly available UK population datasets can be used to identify under-served communities and improve inclusivity in clinical research. They reflect on the challenges and future developments of their approach.
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Next, we focus on this 2022 review by Mohan and Freedman on the persistent under-representation of racial and ethnic minorities in clinical trials, which highlights how this limits the generalisability of safety and efficacy data. They survey key structural and regulatory barriers to participation - such as restrictive eligibility criteria, mistrust, and logistical constraints — and describe recent initiatives and trial designs that have successfully increased diversity. Finally, they argue that pursuing representative enrollment throughout clinical development is not only a matter of equity but also of scientific rigour, as it improves our ability to assess benefit–risk profiles across all populations.
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